Regular Article - Theoretical Physics

Progress in integrative systems biology, physiology and medicine: towards a scale-relative biology

¹ European Institute for Systems Biology and Medicine (EISBM), 7 Parc des Cèdres, Vourles, France
² Department of Physiology, Anatomy and Genetics, Balliol College, Oxford University, Parks Road, Oxford, OX1 3PT, UK
³ LUTH, Observatoire de Paris-Meudon, 5 Place Janssen, 92190, Meudon, France
⁴ 69 Hercules Road, Devon, PL9 8FA, UK

^* e-mail: cauffray@eisbm.org

Received: 28 May 2019
Accepted: 19 November 2019
Published online: 18 March 2020

Abstract

In this paper we present a review of progress in addressing the challenge to understand and describe the vast complexity and multi-level organisation associated with biological systems. We begin with a review of past and current approaches, key lessons, and unresolved challenges, which require a new conceptual framework to address them. After summarizing the core of the problem, which is linked to computational complexity, we review recent developments within the theoretical framework of scale relativity, which offers new insights into the emergence of structure and function (at multiple scales), providing a new integrative approach to biological systems. The theoretical framework describes the critical role of thermodynamics and quantum vacuum fluctuations in the emergence of charge-induced macroscopic quantum fields (effectively a new quantum field theory) at multiple scales, which underpin a macroscopic quantum description of biological systems as a complex exemplar of condensed matter. The theory is validated through a new biomimetic experimental approach, which leads to the emergence of plant and individual cell-like structures with the intrinsic capacity to divide, differentiate and form multicellular structures. We discuss how this theoretical framework could be applied to extend our understanding of cardiac systems biology and physiology, and challenges such as cancer and neurodegenerative disease. We also consider the potential of these new insights to support a new approach to the development of emerging quantum technologies.